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Metronidazole is an antiprotozoal and antibacterial medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria (organism which does not require oxygen for growth) and protozoa. Metronidazole is marketed under the trade name Flagyl in the US, while it is knows as Metizol, Metroniflex, Metronin, Metronix, Metrogel Vaginal, Vandazole, and Flegyl in some other countries.

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Treatment of Anaerobic Infections

Metronidazole is one of the rare examples of a drug developed against a parasite which has since gained broad use as an antibacterial agent. Metronidazole 250 mg is indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. Indicated surgical procedures should be performed in conjunction with Metronidazole therapy. In a mixed aerobic and anaerobic infection, antibiotics appropriate for the treatment of the aerobic infection should be used in addition to Metronidazole / Flagyl.

FDA approved uses

According to the FDA, Metronidazole has activity against protozoans like Entamoeba histolytica, Giardia lamblia and Trichomonas vaginalis, for which the drug was first approved as an effective treatment. Metronidazole is indicated for the treatment of the following infections due to susceptible strains of sensitive organisms: lower respiratory tract infections, including pneumonia, empyema, and lung abscess; skin and skin structure infections; gynecologic infections, including endometritis, endomyometritis.

Metronidazole recommended dosage

The recommended dosage schedule for adults is 7.5 mg/kg infused over one hour every six hours (approximately 500 mg for a 70-kg adult). The first maintenance dose should be instituted six hours following the initiation of the loading dose. A maximum of 4 g should not be exceeded during a 24-hour period. The usual duration of therapy is 7 to 10 days; however, infections of the bone and joint, lower respiratory tract and endocardium may require longer treatment.

Metronidazole possible side effects

Side effects are not commonly seen with this medication unless the patient is taking especially high doses or moderate doses for a long time period. Side effects seen can relate to nausea or appetite loss or side effects can be neurologic. Most cases of toxicity involve very high doses or chronic use of smaller doses. In cases of toxicity, recovery from neurologic signs typically takes a week after the drug is discontinued.