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Celecoxib was shown to be as effective as the maximum prescription-strength NSAIDs, naproxen and ibuprofen in treating arthritis pain and inflammation. Unlike traditional NSAIDs, Celecoxib had no effect on blood clotting and demonstrated no drug interactions with methotrexate and warfarin, therapies commonly taken by arthritis patients. Celecoxib is a breakthrough product for the treatment of arthritis and will fill an unmet medical need for patients.

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How To Use Celecoxib Oral

If you have any questions regarding the information, consult your doctor or pharmacist. Take by mouth, usually once or twice daily, or as directed by your doctor. To decrease the chance of stomach upset, this drug is best taken with food. Dosage is based on your medical condition and response to therapy. The lowest effective dosage should always be used, and only for the prescribed length of time (see also Warning section).

Celebrex Warnings

Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. Therefore, treatment with Celecoxib is not recommended in these patients with advanced renal disease. As with NSAIDs in general, anaphylactoid reactions have occurred in patients without known prior exposure to Celebrex. This document does not contain all possible interactions. Of the Celebrex treated patients in the premarketing controlled clinical trials, approximately 4,250 were patients with OA, approximately 2,100 were patients with RA, and approximately 1,050 were patients with post-surgical pain. Some adverse reactions occurred in higher percentages of patients than in the arthritis pre-marketing trials (treatment durations up to 12 weeks; see Adverse events from Celebrex premarketing controlled arthritis trials).

Possiblr Side Effects

Celebrex is generally well tolerated. It has a lower incidence of stomach side effects than other anti inflammatory drugs, although this medicine can cause stomach bleeding. If you drink alcohol on a daily basis, do not take this medicine without first discussing it with your doctor. Alcohol use combined with this medicine may increase your risk for stomach bleeding. Side effects that may occur while taking this medicine include diarrhea, dizziness, indigestion, stomach pain, gas, nausea, or headache. If they continue or are bothersome, check with your doctor. Fluid retention has also been reported.

Drug Interactions

Clinical studies, as well as post marketing observations, have shown that NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients. Doses up to 2400 mg/day for up to 10 days in 12 patients did not result in serious toxicity. Symptoms following acute NSAID overdoses are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression and coma may occur, but are rare.

Conclusion

Arthritis is the most common cause of long-term disability. By providing a much safer alternative to traditional arthritis therapies, Celebrex will mean significantly better overall management of arthritis