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Using antifungal oral medicine gives you the best chance of curing a severe fungal nail infection. Which medication is used often depends on the type of infection you have.

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Fungal nail infections occur when fungi invade a fingernail or toenail and the skin underneath the nail. Toenails are more commonly affected than fingernails, because they grow very slowly, allowing the fungi more time to develop. You can get a fungal nail infection when you come in contact with the fungi and they begin to grow on or under your nail plate. You can also get an infection by direct contact with an infected person or through contact with floors, shoes, or other personal items, such as nail clippers or nail files, that have fungi on them.

The longer an infection is present and the worse it becomes, the harder it is to treat. Fungal nail infections are difficult to treat, and the medicine is expensive. Future treatment costs could be higher if the infection gets worse. Terbinafine (Lamisil) is a first-line medicine for fungal nail infections caused by dermatophytes. Fluconazole (Diflucan) has not been well studied for fungal nail infections. But research is promising, and it is considered a first-line therapy for infections caused by Candida. Oral antifungal medications often kill fungi but do not immediately improve the appearance of the nail.